当前位置:首页 > 新闻中心 > 科研动态

美国圣路易斯华盛顿大学Guy M. Genin教授来院作学术报告:Reattaching tendon to bone

发布日期:2016-01-13

时间:2016年1月14日上午10点

地点:北校区工科楼1109 机器人与微系统研究中心会议室

报告题目:肌腱与骨的再连接(Reattaching tendon to bone)

 

Guy M. Genin教授是美国圣路易斯华盛顿大学机械工程系和神经外科手术系教授,生物医学工程领域的知名学者,在美国学术界享有盛誉,同时也是西安交通大学的长江学者。

个人网页:http://mems.wustl.edu/people/pages/faculty-bio.aspx?faculty=6

 

 

Reattaching tendon to bone

Guy M. Genin

Professor of Mechanical Engineering and Neurological Surgery, Washington University in St. Louis

Changjiang Professor, Xi’an Jiaotong University

 

Joining of dissimilar materials is a fundamental challenge in engineering.  Nature presents a highly effective solution at the attachment of tendon to bone (the “enthesis") in the rotator cuff of the humeral head. The natural enthesis is far superior to the connection that exists following healing or surgical repair of the rotator cuff: the natural enthesis does not regrow in either instance, and recurrence of tears following surgical repair is as high as 94%. 

 

My collaborators and I study how the natural tendon-to-bone attachment functions, and heals, and how healing might be improved through engineered solutions. Although much of the basic physiology is still debated, it is clear that hierarchical nanoscale-to-milliscale toughening mechanisms are central to tissue resilience, and that mechanical factors play a central role in developing and sustaining these mechanisms.  Hierarchical toughening mechanisms involve tailoring of the collagen lattice upon which the entire tendon-to-bone attachment is constructed, and accommodation by this lattice of a relatively stiff hydroxyl apatite phase.  Toughening strategies include cross-scale functional grading of the mineral component within collagen, macro-scale interdigitation of bony and tendinous tissue, and shape optimization to distribute stresses.

 

Central challenges are understanding how mineral accumulates on the collagen lattice underlying tendon, bone, and its connection, and quantifying the mechanical consequences of adding prescribed amounts of mineral, both to this collagen lattice and to potential scaffolds for guiding healing. This talk will focus on our recent efforts to characterize and reconstitute the nano-to-milliscale physiology of the tendon-to-bone attachment at the humeral head of the rotator cuff.  The talk will conclude with a brief overview of strain mapping techniques we have developed for the purpose of identifying mechanical gradients in tissues and tissue engineered scaffolds.